21900-43-6

Basic information

• Product Name: 4-FLUORO-2-METHYLBENZOYL CHLORIDE 99
• Synonyms: 4-FLUORO-2-METHYLBENZOYL CHLORIDE 99;4-Fluoro-2-methylbenzoyl;4-Fluoro-2-methylbenzoyl chloride 99%;4-Fluoro-o-toluoyl chloride, 2-(Chlorocarbonyl)-5-fluorotoluene
• CAS NO: 21900-43-6
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.5854
• Mol File: 21900-43-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 204.6°Cat760mmHg
• Flash Point: 77.6°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.261mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 4-FLUORO-2-METHYLBENZOYL CHLORIDE 99(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-METHYLBENZOYL CHLORIDE 99(21900-43-6)
• EPA Substance Registry System: 4-FLUORO-2-METHYLBENZOYL CHLORIDE 99(21900-43-6)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 21900-43-6(Hazardous Substances Data)

Usage

General Description

4-FLUORO-2-METHYLBENZOYL CHLORIDE 99 is a chemical compound that is 99% pure and is typically used in organic synthesis and pharmaceutical research. It is a benzoyl chloride derivative with a fluorine and a methyl group attached to the benzene ring. 4-FLUORO-2-METHYLBENZOYL CHLORIDE 99 is a highly reactive acylating agent that is commonly used in the synthesis of various pharmaceutical drugs and organic compounds. It is important to handle this chemical with care due to its reactivity and potential hazards.

InChI:InChI=1/C8H6ClFO/c1-5-4-6(10)2-3-7(5)8(9)11/h2-4H,1H3

Upstream product

• 321-21-1 4-fluoro-2-methylbenzoic acid 

Downstream Products

• 79825-05-1 2-methyl-4-fluoro-4'-methylbenzophenone 
• 1237492-38-4 C₁₄H₉Cl₃FNO₂ 
• 1428858-45-0 2-butyl-4-fluoro-6-methyl-N-(quinolin-8-yl)benzamide 
• 1428858-67-6 2-methyl-4-fluoro-N-(quinolin-8-yl)benzamide 
• 1385064-57-2 6-fluoro-3-phenyl-3-(trifluoromethyl)isochroman-1-one 

Relevant articles and documents

Cu(II)-Catalyzed 6π-Photocyclization of Non-6πSubstrates

This research successfully achieved a Cu(II)-catalyzed 6π-photocyclization of non-6πsubstrates. The photoenolization converts ortho-alkylphenyl alkynl ketones into a triene-type intermediate which undergoes the subsequent 6π-photocyclization to give napht

Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent

The palladium-catalyzed electrochemical C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.

C?O Activation by a Rhodium Bis(N-Heterocyclic Carbene) Catalyst: Aryl Carbamates as Arylating Reagents in Directed C?H Arylation

Despite recent progress in the catalytic transformation of inert phenol derivatives as alternatives to aryl halides and triflates, attempts at the cross-coupling of inert phenol derivatives with the C?H bonds of arenes have met with limited success. Herein, we report the rhodium-catalyzed cross-coupling of aryl carbamates with arenes bearing a convertible directing group. The key to success is the use of an in situ generated rhodium bis(N-heterocyclic carbene) species as the catalyst, which can promote activation of the inert C(sp2)?O bond in aryl carbamates.