5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester
• CAS No.: 157848-08-3
• Molecular Formula: C₁₂H₉Cl₂NO₃
• Molecular Weight: 286.114
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID60356595
• Wikidata: Q72466630
• Mol file: 157848-08-3.mol

Synonyms:157848-08-3;5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester;ethyl 5,7-dichloro-4-hydroxyquinoline-2-carboxylate;ethyl 5,7-dichloro-4-oxo-1H-quinoline-2-carboxylate;SCHEMBL1618153;DTXSID60356595;AKOS015897082;SB68628;AS-35380;FT-0658417;A13926;ethyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate;Q-103189;5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid ethyl ester;Ethyl 5,7-dichloro-1,4-dihydro-4-oxoquinoline-2-carboxylate;Ethyl 5,7-dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylate

Chemical Property of 5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 6.01E-07mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 410.5°Cat760mmHg
• Flash Point: 202°C
• PSA: 59.42000
• Density: 1.444g/cm³
• LogP: 3.42390
• Storage Temp.: 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 284.9959485
• Heavy Atom Count: 18
• Complexity: 397

Purity/Quality:

97% ^*data from raw suppliers

5,7-Dichloro-4-hydroxyquinoline-2-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC(=O)C2=C(N1)C=C(C=C2Cl)Cl

Technology Process of 5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

There total 6 articles about 5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.8%

(Z)-diethyl-3,5-dichloroanilinofumarate (166753-63-5) → ethyl 5,7-dichloro-1,4-dihydro-4-oxoquinoline-2-carboxylate (157848-08-3,166981-79-9)

Guidance literature:

With diphenylether; at 244 ℃; for 0.166667h;

Reference yield: 85.5%

C14H15Cl2NO4 → ethyl 5,7-dichloro-1,4-dihydro-4-oxoquinoline-2-carboxylate (157848-08-3,166981-79-9)

Guidance literature:

With Eaton′s Reagent; In dichloromethane; at 70 ℃; under 2585.81 - 3620.13 Torr; Reagent/catalyst; Solvent; Pressure;

Reference yield:

5,7-dichloro-4-benzyloxyquinoline-2-carboxylic acid, ethyl ester (166981-77-7) → ethyl 5,7-dichloro-1,4-dihydro-4-oxoquinoline-2-carboxylate (157848-08-3,166981-79-9)

Guidance literature:

In hexane; acetonitrile; trifluoroacetic acid;

upstream raw materials:

3,5-Dichloroaniline

diethyl oxaloacetate

5,7-dichloro-4-benzyloxyquinoline-2-carboxylic acid, ethyl ester

(Z)-diethyl-3,5-dichloroanilinofumarate

Downstream raw materials:

5,7-dichlorokynurenic acid

4,5,7-trichloroquinoline

4-hydroxy-5,7-dichloroquinoline

N⁴,N⁴-diethyl-N¹-(5,7-dichloro-[4]quinolyl)-1-methyl-butanediyldiamine

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