2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane

Base Information

• Chemical Name: 2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane
• CAS No.: 438581-35-2
• Molecular Formula: C₂₅H₃₈OS₂Si₂
• Molecular Weight: 474.879
• Mol file: 438581-35-2.mol

Synonyms:2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane

Chemical Property of 2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane

There total 1 articles about 2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trimethylsilyl)-1,3-dithiane (13411-42-2) + 1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane (126822-71-7) → 2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane (438581-35-2)

Guidance literature:

2-(trimethylsilyl)-1,3-dithiane; With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; for 2h;

1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ol025861m

Reference yield:

2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane (438581-35-2) → 3-(tert-butyldiphenylsilanyloxy)-1-(trimethylsilanyl)propan-1-one (438581-36-3)

Guidance literature:

With aluminum oxide; ferric nitrate; In hexane; at 43 ℃; for 1h;

DOI:10.1021/ol025861m

Reference yield:

2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanyl-[1,3]dithiane (438581-35-2) → 5-[4-(tert-butyl-diphenyl-silanyloxy)-2-trimethylsilanyl-but-1-enyl]-2-[2-(4-methoxy-benzyloxy)-ethyl]-furan-3-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 6 steps

1.1: 0.493 g / iron(III) nitrate nonahydrate; basic alumina / hexane / 1 h / 43 °C

2.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C

2.2: 71 percent / diethyl ether; hexane / 0.17 h / -78 °C

3.1: 80 percent / triethylamine; magnesium bromide / CH₂Cl₂ / 3 h / 20 °C

4.1: sodium iodide / acetone / 1 h / 60 °C

5.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

5.2: 0.881 g / tetrahydrofuran / 21 h

6.1: potassium carbonate; palladium(II) acetate; bis-(diphenylphosphino) ferrocene / acetonitrile; H₂O / 12 h / 84 °C

With aluminum oxide; n-butyllithium; palladium diacetate; sodium hydride; potassium carbonate; ferric nitrate; triethylamine; sodium iodide; magnesium bromide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetone; acetonitrile;

DOI:10.1021/ol025861m

upstream raw materials:

2-(trimethylsilyl)-1,3-dithiane

1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane

Downstream raw materials:

3-(tert-butyldiphenylsilanyloxy)-1-(trimethylsilanyl)propan-1-one

(Z)-5-[4-(tert-butyldiphenylsilanyloxy)-2-(trimethylsilanyl)-but-1-enyl]-2-{2-[3-(2-methoxyethoxymethoxy)propyl]-3-methyl-but-3-enyl}furan-3-carboxylic acid methyl ester

1-(tert-butyldiphenylsilanyloxy)-6-chloro-3-(trimethylsilanyl)hex-4-yn-3-ol

benzoic acid 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-chloro-1-(trimethylsilanyl)but-2-ynyl ester