(6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:(6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester
CAS No.:1196662-25-5
Molecular Formula:C₁₉H₂₁FN₂O₄
Molecular Weight:360.385
Hs Code.:

Synonyms:(6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Suppliers and Price of (6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Technology Process of (6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

There total 7 articles about (6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.9%

: 24424-99-5
di-tert-butyl dicarbonate

: 1196662-24-4
2-fluoro-6-(4-methoxybenzylamino)pyridine-3-carbaldehyde

: 1196662-25-5
(6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Guidance literature:: dmap; In tert-butyl alcohol; at 30 ℃;

Reference yield:

: 1513-65-1
2,6-difluoro pyridine

: 1196662-25-5
(6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 90 °C

2: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere

3: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 100 °C / 5171.62 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling

5: manganese(IV) oxide / ethyl acetate / 20 °C

6: dmap / tert-butyl alcohol / 30 °C

With dmap; manganese(IV) oxide; N-Bromosuccinimide; lithium aluminium tetrahydride; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethyl acetate; acetonitrile; tert-butyl alcohol;

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 1196662-25-5
(6-fluoro-5-formylpyridin-2-yl)(4-methoxybenzyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 90 °C

2: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere

3: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 100 °C / 5171.62 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling

5: manganese(IV) oxide / ethyl acetate / 20 °C

6: dmap / tert-butyl alcohol / 30 °C

With dmap; manganese(IV) oxide; N-Bromosuccinimide; lithium aluminium tetrahydride; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethyl acetate; acetonitrile; tert-butyl alcohol;