(2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d

Base Information

Chemical Name:(2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d
CAS No.:1203668-67-0
Molecular Formula:C₁₆H₁₆F₃NO₃
Molecular Weight:327.303
Hs Code.:

Synonyms:(2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d

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Technology Process of (2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d

There total 1 articles about (2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1203668-63-6
(E)-1-(4-nitrobut-3-en-1-yn-1-yl)-4-(trifluoromethyl)benzene

: 590-86-3
isovaleraldehyde

: 1203668-67-0
(2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d

Guidance literature:: (E)-1-(4-nitrobut-3-en-1-yn-1-yl)-4-(trifluoromethyl)benzene; isovaleraldehyde; With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; In chloroform; at -10 ℃; for 18h;

With water; ammonium chloride; optical yield given as %de; enantioselective reaction;
DOI:10.1002/anie.200903905

Reference yield:

: 64-17-5
ethanol

: 1203668-67-0
(2R,3S)-2-isopropyl-3-(nitromethyl)-5-(4-(trifluoromethyl)phenyl)pent-4-ynal 3d

: 1203668-58-9
(2S,3R,4R,Z)-2-ethoxy-3-isopropyl-4-(nitromethyl)-5-(4-(trifluoromethyl)benzylidene)tetrahydrofuran

Guidance literature:: With silver (I) tetrahydrido borate; chloro(triphenylphosphine)silver(I); toluene-4-sulfonic acid; In 2-methyl-but-2-ene; chloroform; at -10 ℃; for 5h; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/anie.200903905