Technology Process of 8-chloro-5-tosyl-11-vinyl-6,11-dihydro-5H-indolo[2,3-b]quinoline
There total 9 articles about 8-chloro-5-tosyl-11-vinyl-6,11-dihydro-5H-indolo[2,3-b]quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
C21H12AuClF9P*CF3O3S(1-)*Ag(1+);
In
nitromethane;
at 20 ℃;
for 2h;
DOI:10.1021/ol5012604
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloro bis(acetonitrile) palladium(II); tri-tert-butyl phosphine; copper(l) iodide; diisopropylamine / toluene / 2 h / 50 °C / Inert atmosphere
2.1: trifluoroacetic acid; sodium nitrite / water / 1 h / 0 °C
2.2: 1 h / 0 °C
3.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C
5.1: C21H12AuClF9P*CF3O3S(1-)*Ag(1+) / nitromethane / 2 h / 20 °C
With
dichloro bis(acetonitrile) palladium(II); potassium phosphate; copper(l) iodide; tri-tert-butyl phosphine; trimethylsilyl trifluoromethanesulfonate; C21H12AuClF9P*CF3O3S(1-)*Ag(1+); diisopropylamine; trifluoroacetic acid; sodium nitrite;
In
tetrahydrofuran; nitromethane; water; toluene; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.1: |Sandmeyer Reaction / 2.2: |Sandmeyer Reaction;
DOI:10.1021/ol5012604
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid; sodium nitrite / water / 1 h / 0 °C
1.2: 1 h / 0 °C
2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C
4.1: C21H12AuClF9P*CF3O3S(1-)*Ag(1+) / nitromethane / 2 h / 20 °C
With
potassium phosphate; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; C21H12AuClF9P*CF3O3S(1-)*Ag(1+); trifluoroacetic acid; sodium nitrite;
In
tetrahydrofuran; nitromethane; water; acetonitrile;
1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction;
DOI:10.1021/ol5012604
![(Z)-N-[(2-azido-4-chlorophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide](/Databaselist/images/loading.webp)
