2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid

Base Information

• Chemical Name: 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid
• CAS No.: 80772-68-5
• Molecular Formula: C₁₆H₂₀O₄S
• Molecular Weight: 308.398
• Mol file: 80772-68-5.mol

Synonyms:2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid

Chemical Property of 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid

There total 3 articles about 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-(2-Cyano-cyclohexylmethylsulfanyl)-phenyl]-acetic acid ethyl ester → 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid (80772-68-5)

Guidance literature:

With potassium hydroxide; In diethylene glycol; at 250 ℃; for 5h;

DOI:10.1021/jm00164a006

Reference yield:

trans-2-(chloromethyl)cyclohexanecarbonitrile (10479-49-9) → 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid (80772-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Na / 1.) ethanol, 2.) reflux, 48 h

2: KOH / bis-(2-hydroxy-ethyl) ether / 5 h / 250 °C

With potassium hydroxide; sodium; In diethylene glycol;

DOI:10.1021/jm00164a006

Reference yield:

ethyl 2-(3-mercaptophenyl)acetate (123964-00-1) → 2-(3-Carboxymethyl-phenylsulfanylmethyl)-cyclohexanecarboxylic acid (80772-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Na / 1.) ethanol, 2.) reflux, 48 h

2: KOH / bis-(2-hydroxy-ethyl) ether / 5 h / 250 °C

With potassium hydroxide; sodium; In diethylene glycol;

DOI:10.1021/jm00164a006

upstream raw materials:

trans-2-(chloromethyl)cyclohexanecarbonitrile

ethyl 2-(3-mercaptophenyl)acetate