1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid

Base Information

• Chemical Name: 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid
• CAS No.: 355022-56-9
• Molecular Formula: C₂₁H₁₅ClN₂O₂
• Molecular Weight: 362.815
• Mol file: 355022-56-9.mol

Synonyms:1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid

Chemical Property of 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid

There total 1 articles about 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-Amino-4-phenylmethylaminobenzoic acid (66315-38-6) + sodium (4-chlorophenyl)(hydroxy)methanesulfonate (46175-04-6) → 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid (355022-56-9)

Guidance literature:

In N,N-dimethyl-formamide; at 140 ℃; for 4h;

DOI:10.1002/1521-4184(200105)334:5<148::AID-ARDP148>3.0.CO;2-S

Reference yield:

1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid (355022-56-9) → 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carbonyl chloride

Guidance literature:

With thionyl chloride; In benzene; at 80 ℃; for 2h;

DOI:10.1002/1521-4184(200105)334:5<148::AID-ARDP148>3.0.CO;2-S

Reference yield:

1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid (355022-56-9) → 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid 4-fluoro-benzylamide

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 2 h / 80 °C

2: CHCl₃ / 0.5 h / 50 °C

With thionyl chloride; In chloroform; benzene;

DOI:10.1002/1521-4184(200105)334:5<148::AID-ARDP148>3.0.CO;2-S

upstream raw materials:

3-Amino-4-phenylmethylaminobenzoic acid

sodium (4-chlorophenyl)(hydroxy)methanesulfonate