66315-38-6

Basic information

• Product Name: 3-AMINO-4-BENZYLAMINO-BENZOIC ACID
• Synonyms: 3-AMINO-4-BENZYLAMINO-BENZOIC ACID;CHEMBRDG-BB 6637286;3-amino-4-(benzylamino)benzoic acid(SALTDATA: FREE)
• CAS NO: 66315-38-6
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.27
• Mol File: 66315-38-6.mol

Chemical Properties

• Boiling Point: 467.3°C at 760 mmHg
• Flash Point: 236.4°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 1.56E-09mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-AMINO-4-BENZYLAMINO-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-BENZYLAMINO-BENZOIC ACID(66315-38-6)
• EPA Substance Registry System: 3-AMINO-4-BENZYLAMINO-BENZOIC ACID(66315-38-6)

Safety Data

• Hazardous Substances Data: 66315-38-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H14N2O2/c15-12-8-11(14(17)18)6-7-13(12)16-9-10-4-2-1-3-5-10/h1-8,16H,9,15H2,(H,17,18)

Upstream product

• 68502-22-7 3-amino-4-benzylamine-benzoic acid methyl ester 
• 100-46-9 benzylamine 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 68502-46-5 4-benzylamine-3-nitro-benzoic acid methyl ester 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 68502-37-4 4-(benzylamino)-3-nitrobenzoic acid 

Downstream Products

• 220143-28-2 1-benzyl-1H-benzotriazole-5-carboxylic acid 
• 355022-56-9 1-benzyl-2-(4-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid 
• 214903-47-6 1-benzyl-2-phenyl-1H-benzimidazole-5-carboxylic acid 
• 174422-19-6 1-Benzyl-2-(2-chloro-phenyl)-1H-benzoimidazole-5-carboxylic acid 

Relevant articles and documents

1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b

1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-raising drug niacin. N

Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity

A series of 1,2-disubstituted benzimidazole-5(6)-carboxamides was prepared and evaluated in vitro for antimicrobial activity against Staphyloccus aureus, Escherichia coli and Candida albicans. The precursor benzimidazolecarboxylic acids 4a-c and 9a-c were

SYNTHESIS OF 1,2-DISUBSTITUTED BENZIMIDAZOLE-5(6)-CARBOXAMIDES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY

A series of 14,N'-(N,N-dialkylaminoethyl)-benzimidazole-5(6) or 5-carboxamides (1-14), having several substituents on the azole and benzene nuclei, were prepared and evalueted in vitro for antimicrobial activity.The precursor bezimidazolecarboxylic acids (15-27) were prepared via oxidative condensation of diaminobenzoic acids and several aldehydes with cupric ion.Compounds 11-14 were prepared by selective regioisomer synthesis.All carboxamides were prepared from the corresponding acids and N,N-dialkylethylenediamine.Antibacterial and antifungal activities were determined as MICs values.Of the synthesized compounds 1-10, 6 and 10 were found to be most favourable.In order to clarify the effect of the substituents at N1 on antimicrobial activity, 12 was prepared by p-chlorobenzyl substitution of compound 6, and increased activity was shown.Compounds 13 and 14, which were prepared by replacement with more bulky alkyl groups on the tert-N atom than 12, gave the best results.