methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Base Information

Chemical Name:methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate
CAS No.:942316-72-5
Molecular Formula:C₁₁H₉ClN₄O₂
Molecular Weight:264.671
Hs Code.:

Synonyms:methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

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Technology Process of methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

There total 5 articles about methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 879016-22-5
5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde

: 5927-18-4
trimethyl phosphonoacetate

: 942316-72-5
methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Guidance literature:: trimethyl phosphonoacetate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde; In tetrahydrofuran; for 0.5h;

Reference yield: 57.0%

: 879016-22-5
5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde

: 942316-72-5
methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Guidance literature:: trimethyl phosphonoacetate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.75h;

5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde; In tetrahydrofuran; for 0.5h;

Reference yield:

: 635-21-2
5-chloroanthranilic acid

: 942316-72-5
methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide; acetic acid / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -78 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 0.5 h

With lithium aluminium tetrahydride; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;