N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide
CAS No.:1092391-51-9
Molecular Formula:C₂₂H₂₀N₆O₃
Molecular Weight:416.439
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

There total 3 articles about N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 6973-60-0
1-Methyl-2-pyrrolecarboxylic acid

: 1092391-99-5
N-[6-(3-aminophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

: 1092391-51-9
N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: 1-Methyl-2-pyrrolecarboxylic acid; With oxalyl dichloride; 6-methyl-2-pyridinecarboxylic acid; In tetrahydrofuran; at 20 ℃; for 1h;

N-[6-(3-aminophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide; In N,N-dimethyl acetamide; at 20 ℃; for 15h;

Reference yield:

: 1092394-65-4
6-(3-nitrophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-amine

: 1092391-51-9
N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl acetamide / 15 h / 20 °C

2.1: hydroxylamine hydrochloride; zinc / methanol / 3 h / Heating / reflux

2.2: 1 h / Heating / reflux

3.1: oxalyl dichloride / 6-methyl-2-pyridinecarboxylic acid / tetrahydrofuran / 1 h / 20 °C

3.2: 15 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; triethylamine; zinc; 6-methyl-2-pyridinecarboxylic acid; In tetrahydrofuran; methanol; N,N-dimethyl acetamide;

Reference yield:

: 1092394-66-5
N-[6-(3-nitrophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

: 1092391-51-9
N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; zinc / methanol / 3 h / Heating / reflux

1.2: 1 h / Heating / reflux

2.1: oxalyl dichloride / 6-methyl-2-pyridinecarboxylic acid / tetrahydrofuran / 1 h / 20 °C

2.2: 15 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; zinc; 6-methyl-2-pyridinecarboxylic acid; In tetrahydrofuran; methanol;