4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

Base Information

Chemical Name:4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine
CAS No.:1312922-47-6
Molecular Formula:C₁₉H₁₄F₅N₃O₂
Molecular Weight:411.331
Hs Code.:

Synonyms:4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

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Chemical Property of 4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

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Technology Process of 4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

There total 6 articles about 4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312922-46-5
3-chloro-6-methyl-5-(6-trifluoromethyl-pyridin-3-yl)-4-(2,4,6-trifluoro-phenyl)-pyridazine

: 124-41-4
sodium methylate

: 1312922-47-6
4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

Guidance literature:: In tetrahydrofuran; methanol; at 55 ℃; for 1h;

Reference yield:

: 597532-36-0
ethyl 6-(trifluoromethyl)nicotinate

: 1312922-47-6
4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -70 °C / Inert atmosphere

1.2: -70 °C

2.1: hydrogen bromide; bromine / acetic acid / 0.5 h / 60 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 16 h / 20 °C

3.2: Cooling

3.3: 1 h

4.1: hydrazine hydrate / butan-1-ol / 4 h / 120 °C

5.1: trichlorophosphate / 0.5 h / 110 °C

6.1: tetrahydrofuran; methanol / 1 h / 55 °C

With n-butyllithium; hydrogen bromide; bromine; hydrazine hydrate; triethylamine; diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; acetic acid; acetonitrile; butan-1-ol;

Reference yield:

: 1312922-42-1
2-methyl-3-oxo-3-(6-trifluoromethyl-pyridin-3-yl)-propionic acid tert-butyl ester

: 1312922-47-6
4-(2,6-difluoro-4-methoxyphenyl)-3-methoxy-6-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide; bromine / acetic acid / 0.5 h / 60 °C / Inert atmosphere

2.1: triethylamine / acetonitrile / 16 h / 20 °C

2.2: Cooling

2.3: 1 h

3.1: hydrazine hydrate / butan-1-ol / 4 h / 120 °C

4.1: trichlorophosphate / 0.5 h / 110 °C

5.1: tetrahydrofuran; methanol / 1 h / 55 °C

With hydrogen bromide; bromine; hydrazine hydrate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; acetic acid; acetonitrile; butan-1-ol;