2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

Base Information

Chemical Name:2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide
CAS No.:1269523-33-2
Molecular Formula:C₂₁H₂₁N₅O₄
Molecular Weight:407.429
Hs Code.:

Synonyms:2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

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Chemical Property of 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

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Technology Process of 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

There total 8 articles about 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carbimidate

: 1269523-33-2
2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

Guidance literature:: With ammonia; In methanol;

Reference yield:

: 1269523-34-3
5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

: 1269523-33-2
2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane / 2 h / 20 °C

2: acetyl chloride / 72 h / 20 °C

3: ammonia / methanol

With ammonia; acetyl chloride; sodium hydroxide; In 1,4-dioxane; methanol;

Reference yield:

: 606490-51-1
2-amino-5-cyanobenzamide

: 1269523-33-2
2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; 1H-imidazole / dichloromethane / 0.5 h / -40 - 20 °C

1.2: 72 h / 20 °C

2.1: sodium hydroxide / 1,4-dioxane / 2 h / 20 °C

3.1: acetyl chloride / 72 h / 20 °C

4.1: ammonia / methanol

With 1H-imidazole; thionyl chloride; ammonia; acetyl chloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane;