5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

Base Information

Chemical Name:5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide
CAS No.:1269523-34-3
Molecular Formula:C₂₁H₂₀N₄O₅
Molecular Weight:408.414
Hs Code.:

Synonyms:5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

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Chemical Property of 5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

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Technology Process of 5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

There total 4 articles about 5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228773-89-4
(R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetic acid

: 606490-51-1
2-amino-5-cyanobenzamide

: 1269523-34-3
5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

Guidance literature:: 2-amino-5-cyanobenzamide; With 1H-imidazole; thionyl chloride; In dichloromethane; at -40 - 20 ℃; for 0.5h;

(R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetic acid; With 1,2,4-Triazole; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1228774-07-9
(R)-tert-butyl 2-hydroxy-2-((R)-3-oxomorpholin-2-yl)acetate

: 1269523-34-3
5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; potassium phosphate; cis-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 4 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 25 °C

3.1: thionyl chloride; 1H-imidazole / dichloromethane / 0.5 h / -40 - 20 °C

3.2: 72 h / 20 °C

With 1H-imidazole; potassium phosphate; copper(l) iodide; thionyl chloride; cis-N,N'-dimethyl-1,2-diaminocyclohexane; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1228773-88-3
(R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate

: 1269523-34-3
5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 25 °C

2.1: thionyl chloride; 1H-imidazole / dichloromethane / 0.5 h / -40 - 20 °C

2.2: 72 h / 20 °C

With 1H-imidazole; thionyl chloride; trifluoroacetic acid; In dichloromethane;