2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

Base Information

Chemical Name:2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride
CAS No.:107027-05-4
Molecular Formula:C₂₀H₂₀N₄O₃*ClH
Molecular Weight:400.865
Hs Code.:

Synonyms:2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

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Chemical Property of 2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

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Technology Process of 2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

There total 13 articles about 2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-53-4
o-toluidine

: 107027-05-4
2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 8 percent / conc. HCl / 5 h / 140 - 150 °C

2: 64 percent / CrO₃, conc. H₂SO₄ / H₂O / 90 - 105 °C

3: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; 1,1'-carbonyldiimidazole; In water;
DOI:10.1021/jm00122a018

Reference yield:

: 1734-79-8
3-(4-nitrophenyl)-2-propenal

: 107027-05-4
2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 8 percent / conc. HCl / 5 h / 140 - 150 °C

2: 64 percent / CrO₃, conc. H₂SO₄ / H₂O / 90 - 105 °C

3: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; 1,1'-carbonyldiimidazole; In water;
DOI:10.1021/jm00122a018

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 107027-05-4
2-(4-Nitro-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 39 percent / methanesulfonic acid / benzene / 36 h / Heating

2: 35 percent / various solvent(s) / 255 °C

3: 98 percent / KOH / aq. ethanol / 2 h / Heating

4: 1.) KOH, Al-foil, 2) HCl, FeCl₃ / 1.) 50percent aq. EtOH, 2.) reflux, 30 min

5: 35 percent / fuming HNO₃ / 2 h / -5 °C

6: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min

With hydrogenchloride; potassium hydroxide; methanesulfonic acid; nitric acid; iron(III) chloride; 1,1'-carbonyldiimidazole; aluminium; In ethanol; benzene;
DOI:10.1021/jm00122a018