ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

Base Information

Chemical Name:ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate
CAS No.:1309366-04-8
Molecular Formula:C₂₆H₃₂N₂O₂
Molecular Weight:404.552
Hs Code.:

Synonyms:ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

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Chemical Property of ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

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Technology Process of ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

There total 11 articles about ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 16419-60-6
2-Methylphenylboronic acid

: ethyl 3‐[6‐bromo‐2‐(tert‐butylamino)quinolin‐3‐yl]‐2‐methylpropanoate

: 1309366-04-8
ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 1.5h;
DOI:10.1039/c9md00085b

Reference yield:

: C₂₆H₃₀N₂O₂

: 1309366-04-8
ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

Guidance literature:: With hydrogen; palladium on carbon; In methanol;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1309366-04-8
ethyl 3‐[2‐(tert‐butylamino)‐6‐(2‐methylphenyl)quinolin‐3‐yl]‐2‐methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

3: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

4: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / ethanol; water / 2 h / 80 °C

5: hydrogen / palladium on carbon / methanol

With hydrogen; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on carbon; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;