3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

Base Information

Chemical Name:3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate
CAS No.:186348-15-2
Molecular Formula:C₄₃H₅₃NO₁₇
Molecular Weight:855.89
Hs Code.:

Synonyms:3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

Chemical Property:

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Technology Process of 3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

There total 8 articles about 3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 186348-00-5
2'-(triisopropylsilyl)-3'-dephenyl-3'-((E)-1-propenyl)-7-(triethylsilyl)-10-acetyl-14β-hydroxydocetaxel 1,14-carbonate

: 186348-15-2
3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; 1.) 0 deg C, 1 h, 2.) RT, overnight;
DOI:10.1021/jm960563e

Reference yield:

: 145533-34-2
14-β-hydroxy-10-deacetylbaccatin III

: 186348-15-2
3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / pyridine / dimethylformamide / 4 h / Ambient temperature

2: 80 percent / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

3: 1.) LiHMDS / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, from -40 deg C to RT, 30 min

4: 1.) LiHMDS / 1.) THF, -45 deg C, 2 min, 2.) THF, -45 deg C, 10 min

5: 80 percent / HF/pyridine / acetonitrile / 1.) 0 deg C, 1 h, 2.) RT, overnight

With pyridine; hydrogen fluoride; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm960563e

Reference yield:

: 156965-59-2
7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III

: 186348-15-2
3'-dephenyl-3'-((E)-1-propenyl)-10-acetyl-14β-hydroxydocetaxel 1,14 carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

2: 1.) LiHMDS / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, from -40 deg C to RT, 30 min

3: 1.) LiHMDS / 1.) THF, -45 deg C, 2 min, 2.) THF, -45 deg C, 10 min

4: 80 percent / HF/pyridine / acetonitrile / 1.) 0 deg C, 1 h, 2.) RT, overnight

With pyridine; hydrogen fluoride; lithium hexamethyldisilazane; In dichloromethane; acetonitrile;
DOI:10.1021/jm960563e