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156965-59-2

7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 156965-59-2 Structure

  • Basic information

    1. Product Name: 7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III
    2. Synonyms: 7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III
    3. CAS NO:156965-59-2
    4. Molecular Formula:
    5. Molecular Weight: 674.861
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 156965-59-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III(156965-59-2)
    11. EPA Substance Registry System: 7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III(156965-59-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 156965-59-2(Hazardous Substances Data)

156965-59-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 156965-59-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,9,6 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 156965-59:
(8*1)+(7*5)+(6*6)+(5*9)+(4*6)+(3*5)+(2*5)+(1*9)=182
182 % 10 = 2
So 156965-59-2 is a valid CAS Registry Number.

156965-59-2Downstream Products

156965-59-2Relevant articles and documents

New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells

Ojima, Iwao,Bounaud, Pierre-Yves,Takeuchi, Craig,Pera, Paula,Bernacki, Ralph J.

, p. 189 - 194 (1998)

New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

A new rearrangement of oxetane-type taxoids

Appendino, Giovanni,Varese, Marcella,Gariboldi, Pierluigi,Gabetta, Bruno

, p. 2217 - 2220 (1994)

Treatment of 7-triethylsilyl-14β-hydroxy-10-deacetylbaccatin III (1b) with pyridinium p-toluenesulfonate in refluxing benzene gave the orthoester 3 as a result of O(2) → O(14) benzoate migration, contraction of ring A followed by formation of an ether bri

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

Ojima, Iwao,Borella, Christopher P.,Wu, Xinyuan,Bounaud, Pierre-Yves,Oderda, Cecilia Fumero,Sturm, Matthew,Miller, Michael L.,Chakravarty, Subrata,Chen, Jin,Huang, Qing,Pera, Paula,Brooks, Tracy A.,Baer, Maria R.,Bernacki, Ralph J.

, p. 2218 - 2228 (2007/10/03)

A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure - activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters.

TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

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Page 5-10, (2008/06/13)

The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.

Syntheses and structure-activity relationships of taxoids derived from 14β-hydroxy-10-deacetylbaccatin III

Ojima, Iwao,Slater, John C.,Kuduk, Scott D.,Takeuchi, Craig S.,Gimi, Rayomand H.,Sun, Chung-Ming,Park, Young Hoon,Pera, Paula,Veith, Jean M.,Bernacki, Ralph J.

, p. 267 - 278 (2007/10/03)

A series of new taxoids derived from 14β-hydroxy-10-deacetylbaccatin III was synthesized by means of the β-lactam synthon method. Most of the new taxoids thus synthesized possess excellent cytotoxicity against human ovarian (A121), non-small-cell lung (A5

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