(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Base Information

Chemical Name:(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane
CAS No.:136262-65-2
Molecular Formula:C₃₈H₆₂O₅Si₂
Molecular Weight:655.078
Hs Code.:

(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Synonyms:(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Suppliers and Price of (2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

There total 15 articles about (2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 136262-64-1
(E)-(3R,4S,6S)-1-{(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-7-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-6-methyl-hept-1-en-3-ol

: 77-78-1
dimethyl sulfate

: 136262-65-2
(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00019a004

Reference yield:

: 123444-68-8
(S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal

: 136262-65-2
(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Guidance literature:: Multi-step reaction with 11 steps

2: DIBAH

3: L-(+)-DIPT, TBHP, TIP / -30 °C

4: Ph₃P, I₂, Im

5: n-BuLi / tetrahydrofuran / -78 deg C to room temp.

7: 1.) O₃, KOH / CH₂Cl₂

8: 78 percent

9: 80 percent / K₂CO₃ / 18-C-6 / toluene

10: Zn(BH₄)2 / diethyl ether / -45 °C

11: 81 percent / NaH / tetrahydrofuran

With tert.-butylhydroperoxide; potassium hydroxide; n-butyllithium; zinc(II) tetrahydroborate; L-(+)-diisopropyl tartrate; impramine; iodine; sodium hydride; diisobutylaluminium hydride; isobutyltriphenylphosphonium bromide; potassium carbonate; ozone; triphenylphosphine; 18-crown-6 ether; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo00019a004

Reference yield:

: 136262-53-8
(3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile

: 136262-65-2
(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[(E)-(3R,4S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-3,4-dimethoxy-6-methyl-hept-1-enyl]-2-methyl-oxirane

Guidance literature:: Multi-step reaction with 12 steps

1: DIBAH / diethyl ether

3: DIBAH

4: L-(+)-DIPT, TBHP, TIP / -30 °C

5: Ph₃P, I₂, Im

6: n-BuLi / tetrahydrofuran / -78 deg C to room temp.

8: 1.) O₃, KOH / CH₂Cl₂

9: 78 percent

10: 80 percent / K₂CO₃ / 18-C-6 / toluene

11: Zn(BH₄)2 / diethyl ether / -45 °C

12: 81 percent / NaH / tetrahydrofuran

With tert.-butylhydroperoxide; potassium hydroxide; n-butyllithium; zinc(II) tetrahydroborate; L-(+)-diisopropyl tartrate; impramine; iodine; sodium hydride; diisobutylaluminium hydride; isobutyltriphenylphosphonium bromide; potassium carbonate; ozone; triphenylphosphine; 18-crown-6 ether; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo00019a004