2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Base Information

Chemical Name:2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
CAS No.:1332951-83-3
Molecular Formula:C₂₇H₂₁ClN₈O₂
Molecular Weight:524.969
Hs Code.:

Synonyms:2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

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Chemical Property of 2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

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Technology Process of 2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

There total 8 articles about 2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332951-97-9
2-Chloro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]-triazin-2-yl]benzoic acid

: (1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethanamine trifluoroacetate

: 1332951-83-3
2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Guidance literature:: 2-Chloro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]-triazin-2-yl]benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.25h;

(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethanamine trifluoroacetate; In N,N-dimethyl-formamide;

In N,N-dimethyl-formamide; pH=10; Alkaline conditions;

Reference yield:

: 5332-25-2
6-bromoquinoline

: 1332951-83-3
2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 24 h / 30 °C / Inert atmosphere

2.1: L-proline / chloroform / 0 - 20 °C

3.1: butan-1-ol / 22 h / 110 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

4.2: pH 4 - 5

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h

5.3: pH 10 / Alkaline conditions

With N-Methyldicyclohexylamine; water; N-ethyl-N,N-diisopropylamine; HATU; L-proline; lithium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1332951-95-7
methyl 2-chloro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoate

: 1332951-83-3
2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

1.2: pH 4 - 5

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h

2.3: pH 10 / Alkaline conditions

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;