9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

Base Information

Chemical Name:9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine
CAS No.:183051-98-1
Molecular Formula:C₂₁H₂₃N₇O₅
Molecular Weight:453.458
Hs Code.:

Synonyms:9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

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Chemical Property of 9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

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Technology Process of 9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

There total 6 articles about 9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 107-11-9,30551-89-4
1-amino-2-propene

: 183051-95-8
9-((2R,4aR,6R,8aS)-8-Nitro-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

: 183051-98-1
9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

Guidance literature:: With potassium fluoride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1080/07328319808004672

Reference yield:

: 39798-19-1
Adenosine dialdehyde

: 183051-98-1
9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / H₂O

2: 33 percent / zinc chloride / 6 h / Ambient temperature

3: 98 percent / pyridine, acetic anhydride / CH₂Cl₂ / 2 h / 0 °C / other reagents: methanesulfonic acid, 4-(dimethylamino)pyridine/acetic anhydride

4: 85 percent / potassium fluoride / tetrahydrofuran / 2 h / Heating

With pyridine; potassium fluoride; sodium hydroxide; acetic anhydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1080/07328319808004672

Reference yield:

: 183051-91-4
(2R,4aR,6R,7R,8R,8aS)-6-(6-Amino-purin-9-yl)-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 183051-98-1
9-((2R,4aR,6R,7R,8R,8aS)-7-Allylamino-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine, acetic anhydride / CH₂Cl₂ / 2 h / 0 °C / other reagents: methanesulfonic acid, 4-(dimethylamino)pyridine/acetic anhydride

2: 85 percent / potassium fluoride / tetrahydrofuran / 2 h / Heating

With pyridine; potassium fluoride; acetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1080/07328319808004672