N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Chemical Name:N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
CAS No.:1609170-46-8
Molecular Formula:C₂₉H₃₅N₇O₃S
Molecular Weight:561.708
Hs Code.:

Synonyms:N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Chemical Property of N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Technology Process of N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

There total 11 articles about N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190399-71-3
4-hydroxy-3-methyl-6-methylmercaptopyrazolo[3,4-d]pyrimidine

: 1609170-46-8
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / N,N-dimethyl-aniline / 1 h / Reflux

2.1: isopropyl alcohol / 3 h / Reflux

2.2: 0.5 h / Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4.5 h / 0 - 20 °C

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-aniline; isopropyl alcohol;

Reference yield:

: 1190399-72-4
4-chloro-3-methyl-6-methylmercaptopyrazolo[3,4-d]pyrimidine

: 1609170-46-8
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 3 h / Reflux

1.2: 0.5 h / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4.5 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; isopropyl alcohol;

Reference yield:

: 6627-55-0
2-bromo-p-cresol

: 1609170-46-8
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / water / 24 h / 100 °C

2: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3: trifluoroacetic acid; sodium nitrite / 12 h / 0 - 20 °C

4: palladium on activated charcoal; hydrogen / tetrahydrofuran / 12 h / 20 °C

5: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

6: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 1 h / 135 °C / Inert atmosphere

7: triethylamine; hydrogen; platinum(IV) oxide; acetic acid / 24 h / 20 °C / 4551.02 Torr

8: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With platinum(IV) oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium on activated charcoal; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;