N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Base Information

Chemical Name:N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
CAS No.:1609170-48-0
Molecular Formula:C₃₀H₃₇N₇O₃S
Molecular Weight:575.735
Hs Code.:

N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Synonyms:N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Chemical Property of N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

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Technology Process of N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

There total 13 articles about N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1609170-46-8
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

: 1609170-48-0
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: With sodium cyanoborohydride; acetic acid; at 20 ℃; for 0.5h;

Reference yield:

: 1190399-71-3
4-hydroxy-3-methyl-6-methylmercaptopyrazolo[3,4-d]pyrimidine

: 1609170-48-0
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / N,N-dimethyl-aniline / 1 h / Reflux

2.1: isopropyl alcohol / 3 h / Reflux

2.2: 0.5 h / Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4.5 h / 0 - 20 °C

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

5.1: acetic acid; sodium cyanoborohydride / 0.5 h / 20 °C

With sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-aniline; isopropyl alcohol;

Reference yield:

: 1190399-72-4
4-chloro-3-methyl-6-methylmercaptopyrazolo[3,4-d]pyrimidine

: 1609170-48-0
N-4-((2-isopropylsulfonyl)phenyl)-3-methyl-N-6-(5-methyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 3 h / Reflux

1.2: 0.5 h / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4.5 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

4.1: acetic acid; sodium cyanoborohydride / 0.5 h / 20 °C

With sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; isopropyl alcohol;