3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

Base Information

• Chemical Name: 3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile
• CAS No.: 934022-39-6
• Molecular Formula: C₁₆H₂₂N₂O
• Molecular Weight: 258.363
• Mol file: 934022-39-6.mol

Synonyms:3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

Chemical Property of 3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

There total 2 articles about 3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methylamino)propanenitrile (77784-81-7) + allyl bromide (106-95-6) → 3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile (934022-39-6)

Guidance literature:

3-(N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methylamino)propanenitrile; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

allyl bromide; With tetrabutylammomium bromide; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;

DOI:10.1016/j.tetlet.2007.01.047

Reference yield:

pseudoephedrine (90-82-4,7009-81-6,90-83-5,6912-63-6) → 3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile (934022-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 99 percent / methanol

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 97 percent / tetrabutylammonium bromide / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2007.01.047

Reference yield:

3-(N-((1S,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile (934022-39-6) → C13H19NO2

Guidance literature:

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2007.01.047

upstream raw materials:

3-(N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

allyl bromide

pseudoephedrine

Downstream raw materials:

(2S,3S,4R,5R)-3,4,5-trimethyl-2-phenylmorpholine 4-oxide