Technology Process of 2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate
There total 8 articles about 2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dichloromethame / 16 h / 0 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h
3.1: acetic acid; toluene / 1.5 h / 150 °C / Irradiation
4.1: sodium tetrahydroborate / methanol; dichloromethane / 17 h / 20 °C
4.2: 4 h
5.1: lithium iodide / 2,4,6-trimethyl-pyridine / 1.5 h / 200 °C / Irradiation
6.1: hydrogen bromide / water / 1 h / 150 °C / Irradiation
7.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
With
sodium tetrahydroborate; hydrogen bromide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; lithium iodide;
palladium 10% on activated carbon;
In
2,4,6-trimethyl-pyridine; methanol; dichloromethame; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h
2.1: acetic acid; toluene / 1.5 h / 150 °C / Irradiation
3.1: sodium tetrahydroborate / methanol; dichloromethane / 17 h / 20 °C
3.2: 4 h
4.1: lithium iodide / 2,4,6-trimethyl-pyridine / 1.5 h / 200 °C / Irradiation
5.1: hydrogen bromide / water / 1 h / 150 °C / Irradiation
6.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
With
sodium tetrahydroborate; hydrogen bromide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; lithium iodide;
palladium 10% on activated carbon;
In
2,4,6-trimethyl-pyridine; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;
