2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

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Chemical Name:2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate
CAS No.:1000016-79-4
Molecular Formula:C₂₉H₃₅N₃O₄
Molecular Weight:489.615
Hs Code.:

Synonyms:2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

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Chemical Property of 2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

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Technology Process of 2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

There total 8 articles about 2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895569-32-1
3-(7-hydroxy-1-oxo-1H-isoquinolin-2-yl)-4-methylbenzoic acid

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 1000016-79-4
2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

Reference yield:

: 10397-30-5
4-methyl-3-nitrobenzoyl chloride

: 1000016-79-4
2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethame / 16 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

3.1: acetic acid; toluene / 1.5 h / 150 °C / Irradiation

4.1: sodium tetrahydroborate / methanol; dichloromethane / 17 h / 20 °C

4.2: 4 h

5.1: lithium iodide / 2,4,6-trimethyl-pyridine / 1.5 h / 200 °C / Irradiation

6.1: hydrogen bromide / water / 1 h / 150 °C / Irradiation

7.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

With sodium tetrahydroborate; hydrogen bromide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; lithium iodide; palladium 10% on activated carbon; In 2,4,6-trimethyl-pyridine; methanol; dichloromethame; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 303133-89-3
N-cyclopropyl-4-methyl-3-nitrobenzamide

: 1000016-79-4
2-pyrrolidin-1-ylethyl 4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

2.1: acetic acid; toluene / 1.5 h / 150 °C / Irradiation

3.1: sodium tetrahydroborate / methanol; dichloromethane / 17 h / 20 °C

3.2: 4 h

4.1: lithium iodide / 2,4,6-trimethyl-pyridine / 1.5 h / 200 °C / Irradiation

5.1: hydrogen bromide / water / 1 h / 150 °C / Irradiation

6.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

With sodium tetrahydroborate; hydrogen bromide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; lithium iodide; palladium 10% on activated carbon; In 2,4,6-trimethyl-pyridine; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;