5-(Tributylstannyl)-1,3-thiazole

Base Information

Chemical Name:5-(Tributylstannyl)-1,3-thiazole
CAS No.:157025-33-7
Molecular Formula:C15H29 N S Sn
Molecular Weight:374.178
Hs Code.:2934100090
European Community (EC) Number:677-928-3
DSSTox Substance ID:DTXSID90376847
Wikidata:Q72510127
Mol file:157025-33-7.mol

Synonyms:157025-33-7;5-(Tributylstannyl)thiazole;5-(Tributylstannyl)-1,3-thiazole;tributyl(1,3-thiazol-5-yl)stannane;Thiazole, 5-(tributylstannyl)-;Tributyl(thiazol-5-yl)stannane;MFCD01319074;5-Tributylstannylthiazole;5-tributylstannyl thiazole;5-Tributylstannanylthiazole;5-tributylstannanyl thiazole;5-tributylstannanyl-thiazole;5-tri-n-butylstannylthiazole;SCHEMBL27285;5-(tributylstannyl)-thiazole;5-(tri-n-butylstannyl)thiazole;5-tributylstannyl-1,3-thiazol;DTXSID90376847;GOWNSHUNTJWVOM-UHFFFAOYSA-N;5-(tributylstannanyl)-1,3-thiazole;AKOS015839505;GS-6474;SY065279;FT-0685300;EN300-218268;H10390;A809797;J-516428

Suppliers and Price of 5-(Tributylstannyl)-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Tributylstannylthiazole
5g
$ 1320.00

SynQuest Laboratories
5-(Tributylstannyl)-1,3-thiazole
250 mg
$ 40.00

SynQuest Laboratories
5-(Tributylstannyl)-1,3-thiazole
1 g
$ 116.00

SynQuest Laboratories
5-(Tributylstannyl)-1,3-thiazole
5 g
$ 448.00

Medical Isotopes, Inc.
5-Tributylstannylthiazole
1 g
$ 290.00

Matrix Scientific
5-(Tributylstannyl)thiazole 93%
5g
$ 824.00

Matrix Scientific
5-(Tributylstannyl)thiazole 93%
1g
$ 286.00

Matrix Scientific
5-(Tributylstannyl)thiazole 93%
500mg
$ 227.00

Apolloscientific
5-(Tributylstannyl)-1,3-thiazole
5g
$ 406.00

Apolloscientific
5-(Tributylstannyl)-1,3-thiazole
1g
$ 105.00

Total 29 raw suppliers

Chemical Property of 5-(Tributylstannyl)-1,3-thiazole

Chemical Property:

Vapor Pressure:1.42E-05mmHg at 25°C
Boiling Point:377.9°C at 760 mmHg
PKA:2.72±0.10(Predicted)
Flash Point:182.3°C
PSA：41.13000
LogP:5.19920
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:10
Exact Mass:375.104274
Heavy Atom Count:18
Complexity:189

Purity/Quality:

97% ^*data from raw suppliers

5-Tributylstannylthiazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 21-23-25-36/38-48-50/53
Safety Statements: 23-26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC[Sn](CCCC)(CCCC)C1=CN=CS1
Uses 5-Tributylstannylthiazole is used in the synthetic preparation of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

Technology Process of 5-(Tributylstannyl)-1,3-thiazole

There total 5 articles about 5-(Tributylstannyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 3034-55-7
5-bromo-1,3-thiazole

: 1461-22-9
tributyltin chloride

: 157025-33-7
5-(tributylstannanyl)-1,3-thiazole

Guidance literature:: 5-bromo-1,3-thiazole; With n-butyllithium; In diethyl ether; hexane; at -70 ℃; for 0.5h; Inert atmosphere;

tributyltin chloride; In diethyl ether; hexane; at -70 - 20 ℃; for 6h;

Reference yield:

: 263868-71-9
5-(tributylstannyl)-2-(trimethylsilyl)thiazole

: 157025-33-7
5-(tributylstannanyl)-1,3-thiazole

Guidance literature:: With methanol; aluminum oxide; ammonia; In chloroform;

Reference yield:

: 1461-22-9
tributyltin chloride

: 79265-30-8
2-(trimethylsilyl)thiazole

: 157025-33-7
5-(tributylstannanyl)-1,3-thiazole

Guidance literature:: 2-(trimethylsilyl)thiazole; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

tributyltin chloride; In diethyl ether; hexane; at 20 ℃; for 1h;