N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

Base Information

Chemical Name:N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea
CAS No.:188257-52-5
Molecular Formula:C₆₁H₅₈N₂O₁₁S
Molecular Weight:1027.2
Hs Code.:

Synonyms:N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

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Technology Process of N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

There total 9 articles about N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 188257-47-8
(3-(aminomethyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)phenyl)methanol

: dipivaloylfluorescein isothiocyanate

: 188257-52-5
N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1080/15257779908043075

Reference yield:

: 618-88-2
5-nitrobenzene-1,3-dicarboxylic acid

: 188257-52-5
N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / H₂ / Pd/C / methanol / 1 h / 20 °C / 760 Torr

2: 82 percent / conc. H₂SO₄ / 16 h / Heating

3: 82 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: 1.) aq. NaNO₂, aq. HCl / 1.) -5 deg C, 30 min, 2.) H₂O, 0 deg C, 2 h

5: 52.3 percent / pyridine / 20 °C

6: 79 percent / LiAlH₄ / diethyl ether

7: 78 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; hydrogen; triethylamine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1080/15257779908043075

Reference yield:

: 3326-32-7,27072-45-3
fluorescein isothiocyanate

: 188257-52-5
N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / iPr₂NEt / tetrahydrofuran / 12 h / Ambient temperature

2: 78 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1080/15257779908043075