4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

Base Information

Chemical Name:4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose
CAS No.:154367-75-6
Molecular Formula:C₂₇H₄₃IO₈SeSi
Molecular Weight:729.584
Hs Code.:

Synonyms:4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

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Chemical Property of 4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

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Technology Process of 4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

There total 8 articles about 4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: acetyl 4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-β-D-galacto-pyranoside

: 4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-β-D-galacto-pyranose

: 154367-75-6
4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

Guidance literature:: With hydrazine; In methanol; at 0 - 23 ℃; Yield given. Title compound not separated from byproducts;
DOI:10.1021/ja00113a013

Reference yield:

: Acetic acid (2R,3S,4S,5R,6S)-6-acetoxy-4-[(2R,3S,4R,5S,6R)-4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-5-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-methyl-5-phenylselanyl-tetrahydro-pyran-3-yl ester

: 4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-β-D-galacto-pyranose

: 154367-75-6
4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

Guidance literature:: With hydrazine; In methanol; at 23 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)91806-9

Reference yield:

: 134355-03-6
6-deoxy-D-glucal

: 154367-75-6
4-O-acetyl-3-O<3-O-((tert-butyldimethyl)silyl)-2,6-dideoxy-2-iodo-4-O-methyl-α-D-talo-pyranosyl>-2,6-dideoxy-2-(selenophenyl)-α-D-galacto-pyranose

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dimethylformamide

2: Et₃N, DMAP / CH₂Cl₂

3: 1) CH₂Cl₂, 0 deg C, 2) THF

4: 88 percent / HF*pyridine / tetrahydrofuran

5: 63 percent / I(coll)2ClO₄ / CH₂Cl₂ / 23 °C

6: NH₂NH₂ / methanol / 23 °C

With dmap; iodonium(di-γ-collidine) perchlorate; pyridine hydrogenfluoride; triethylamine; hydrazine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)91806-9