RACEMIC-4-HYDROXY[2,2]PARACYCLOPHANE

Base Information

• Chemical Name: RACEMIC-4-HYDROXY[2,2]PARACYCLOPHANE
• CAS No.: 157018-15-0
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.302
• Mol file: 157018-15-0.mol

Synonyms:RACEMIC-4-HYDROXY[2,2]PARACYCLOPHANE;RACEMIC-4,12-DIHYDROXY[2.2]PARACYCLOPHANE, MIN. 97%;racemic-4-Hydroxy[2.2]paracyclophane,min.97%

Chemical Property of RACEMIC-4-HYDROXY[2,2]PARACYCLOPHANE

Chemical Property:

• Melting Point: 229-230 °C
• Boiling Point: 367.1±31.0 °C(Predicted)
• PKA: 10.22±0.20(Predicted)
• PSA: 20.23000
• Density: 1.121±0.06 g/cm3(Predicted)
• LogP: 3.27600

Purity/Quality:

97% ^*data from raw suppliers

racemic-4-Hydroxy[2.2]paracyclophane, min. 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RACEMIC-4-HYDROXY[2,2]PARACYCLOPHANE

There total 66 articles about RACEMIC-4-HYDROXY[2,2]PARACYCLOPHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(Rp)-(-)-4-bromo-12-hydroxy-[2.2]paracyclophane → (Rp)-(+)-4-hydroxy-[2.2]paracyclophane (157018-15-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 3h;

DOI:10.1016/j.tetasy.2007.12.010

Reference yield: 95.0%

(+)-(S)-4-acetoxy[2.2]paracyclophane → (Sp)-4-hydroxy-[2.2]paracyclophane (157018-15-0)

Guidance literature:

With potassium hydroxide; In methanol; Ambient temperature;

Reference yield: 94.1%

4-bromo[2.2]paracyclophane (1908-61-8,37503-79-0) → 4-hydroxy-[2,2]-paracyclophane (5628-11-5,157018-15-0)

Guidance literature:

4-bromo[2.2]paracyclophane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - 0 ℃; for 0.666667h; Inert atmosphere;

With Trimethyl borate; In diethyl ether; pentane; at 20 ℃; for 1h;

With water; dihydrogen peroxide; sodium hydroxide; at 20 ℃;

DOI:10.1021/ol201080c

upstream raw materials:

[2.2]Paracyclophan

4-bromo[2.2]paracyclophane

4-amino[2.2]paracyclophane

acetic acid

Downstream raw materials:

<2.2>paracyclophane-4,7-dione

<2.2>paracyclophane-4,5-quinone