9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide

Base Information

• Chemical Name: 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide
• CAS No.: 1374606-56-0
• Molecular Formula: C₃₀H₃₃N₉O₂
• Molecular Weight: 551.651

Synonyms:9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide

Chemical Property of 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide

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Technology Process of 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide

There total 3 articles about 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

9-(2-azidoethylamino)-N-(2-(dimethylamino)ethyl)acridine-3-carboxamide (1196472-25-9) + 2-amino-N-(prop-2-yn-1-yl)benzamide (4943-83-3) → 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide (1374606-56-0)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1002/cmdc.201200060

Reference yield:

2-nitrobenzyl chloride (610-14-0) → 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide (1374606-56-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: Al/Hg amalgam / diethyl ether; ethanol; water / 2 h / 20 °C

3: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With copper(II) sulfate; sodium L-ascorbate; triethylamine; In diethyl ether; ethanol; dichloromethane; water; tert-butyl alcohol;

DOI:10.1002/cmdc.201200060

Reference yield:

9-chloro-N-(2-(dimethylamino)ethyl)acridine-3-carboxamide → 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide (1374606-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: phenol / 55 °C

2: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; phenol;

DOI:10.1002/cmdc.201200060

upstream raw materials:

9-(2-azidoethylamino)-N-(2-(dimethylamino)ethyl)acridine-3-carboxamide

2-amino-N-(prop-2-yn-1-yl)benzamide

2-nitrobenzyl chloride

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