Pyrazolo[1,5-a]pyridin-5-ol

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridin-5-ol
• CAS No.: 156969-42-5
• Molecular Formula: C7H6 N2 O
• Molecular Weight: 134.137
• Hs Code.: 2933998090
• Mol file: 156969-42-5.mol

Synonyms:5-Hydroxypyrazolo[1,5-a]pyridine

Chemical Property of Pyrazolo[1,5-a]pyridin-5-ol

Chemical Property:

• PKA: 6.53±0.53(Predicted)
• PSA: 37.53000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 1.03990

Purity/Quality:

98%min ^*data from raw suppliers

Pyrazolo[1,5-a]pyridin-5-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyridin-5-ol

There total 12 articles about Pyrazolo[1,5-a]pyridin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 5-methoxypyrazolo[1,5-a]pyridine-3-carboxylate (99446-53-4) → pyrazolo<1,5-a>pyridin-5-ol (156969-42-5)

Guidance literature:

ethyl 5-methoxypyrazolo[1,5-a]pyridine-3-carboxylate; With sulfuric acid; water; for 18h; Reflux;

With sodium hydroxide; In water; pH=7;

DOI:10.1016/j.bmc.2011.11.029

Reference yield: 88.0%

→ pyrazolo<1,5-a>pyridin-5-ol (156969-42-5)

Guidance literature:

Reference yield: 80.1%

5-methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester (99446-31-8) → pyrazolo<1,5-a>pyridin-5-ol (156969-42-5)

Guidance literature:

With hydrogen bromide; for 16h; Reflux;

upstream raw materials:

3-Methylpyrazole

Propiolic acid

3-methyl-1-propynoylpyrazole

5-methyl-1-propynoylpyrazole

Downstream raw materials:

5-methoxypyrazolo[1,5-a]pyridine

5-(2-chloro-4-nitrophenoxy)pyrazolo[1,5-a]pyridine

N'-((5-methoxypyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

3-((2-methyl-2-(2-methyl-5-nitrophenylsulfonyl)-hydrazono)methyl)pyrazolo[1,5-a]pyridin-5-yl acetate

Refernces

• 1、 M?ller, Dorothee,Kling, Ralf C.,Skultety, Marika,Leuner, Kristina,Hübner, Harald,Gmeiner, Peter. "Functionally selective dopamine D2, D3 receptor partial agonists". supporting information. p. 4861 - 4875. Retrieved 2014/07/07.
• 2、 -. "PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES". Page/Page column 88; 89. . Retrieved 2013/09/12.