trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester
CAS No.:955373-76-9
Molecular Formula:C₂₀H₁₇Cl₂F₆N₃O₆S₂
Molecular Weight:644.4
Hs Code.:

trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

Synonyms:trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

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Chemical Property of trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

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Technology Process of trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

There total 7 articles about trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[R]-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-2-one

: 358-23-6
trifluoromethylsulfonic anhydride

: 955373-77-0
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-phenyl ester

: 955373-76-9
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

Guidance literature:: With pyridine; In dichloromethane; at -78 ℃; for 48h;

Reference yield:

: 955373-74-7
3-[R]-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,5,6,7-tetrahydro-3H-benzimidazole-3-yl)-pyrrolidin-2-one

: 955373-77-0
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-phenyl ester

: 955373-76-9
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 40 °C / 1551.49 Torr

2: pyridine / dichloromethane / 48 h / -78 °C

With pyridine; hydrogen; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 886616-14-4
5-benzyloxy-2-bromomethyl-1,3-dichloro-benzene

: 955373-77-0
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-phenyl ester

: 955373-76-9
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-pheny ester

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

2: formic acid / acetone / 24 h

3: sodium cyanoborohydride / methanol / 2 h / 50 °C

4: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 40 °C / 1551.49 Torr

5: pyridine / dichloromethane / 48 h / -78 °C

With pyridine; formic acid; hydrogen; sodium cyanoborohydride; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone;