4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole

Base Information

• Chemical Name: 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole
• CAS No.: 137882-21-4
• Molecular Formula: C₂₁H₂₁N₃O
• Molecular Weight: 331.417
• Mol file: 137882-21-4.mol

Synonyms:4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole

Chemical Property of 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole

Chemical Property:

Purity/Quality:

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Technology Process of 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole

There total 2 articles about 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methylhydrazine (60-34-4) + ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate (137860-26-5) → 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole (137882-21-4)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1248/cpb.42.1617

Reference yield:

ethyl butyroyl acetate (3249-68-1) → 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole (137882-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / diisopropylethylamine, LiCl / tetrahydrofuran / 15 h / Heating

2: 82 percent / ethanol / 3 h / Heating

With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.42.1617

Reference yield: 75.0%

4-<(2'-cyanobiphenyl-4-yl)methyl>-5-hydroxy-1-methyl-3-n-propylpyrazole (137882-21-4) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<(N,N-dimethylcarbamoyl)oxy>-1-methyl-3-n-propylpyrazole (137860-33-4)

Guidance literature:

With triethylamine; In dichloromethane; for 10h; Heating;

DOI:10.1248/cpb.42.1617

upstream raw materials:

methylhydrazine

ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate

ethyl butyroyl acetate

Downstream raw materials:

4'-[1-Methyl-5-(2-morpholin-4-yl-2-oxo-ethoxy)-3-propyl-1H-pyrazol-4-ylmethyl]-biphenyl-2-carbonitrile

ethyl 2-<4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methyl-3-n-propylpyrazol-5-yl>oxyacetate

4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<(N,N-dimethylcarbamoyl)oxy>-1-methyl-3-n-propylpyrazole