N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

Base Information

Chemical Name:N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide
CAS No.:1609429-13-1
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

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Chemical Property of N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

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Technology Process of N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

There total 3 articles about N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.5%

: 10602-00-3
4-Ethynyl-benzoic acid

: 669067-80-5
4-(6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-yl)-butan-1-amine

: 1609429-13-1
N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm5001453

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1609429-13-1
N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Reflux; Inert atmosphere

3: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm5001453

Reference yield:

: 669067-79-2
4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butanenitrile

: 1609429-13-1
N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-ethynylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Reflux; Inert atmosphere

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm5001453