2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine
CAS No.:263718-69-0
Molecular Formula:C₂₁H₃₂N₂O₃Si
Molecular Weight:388.582
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Suppliers and Price of 2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

There total 10 articles about 2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 263718-68-9
2-[1-azido-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(2-methoxymethoxy-phenyl)-pyridine

: 263718-69-0
2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.3987/COM-99-S78

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 263718-69-0
2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / imidazole / dimethylformamide / 1 h / 25 °C

2: trimethylamine N-oxide / OsO₄ / acetone; H₂O / 2 h / 25 °C

3: NaIO₄ / methanol; H₂O / 2 h / 0 °C

4: NaBH₄ / methanol; H₂O / 0.17 h / 25 °C

5: 99 percent / DMAP / CH₂Cl₂ / 0.67 h / 0 - 25 °C

6: NaN₃ / dimethylsulfoxide / 25 °C

7: 77 percent / 2M aq. Na₂CO₃ / Pd(Ph₃P)4 / benzene; ethanol / 36 h / reflux

8: 100 percent / H₂ / 5 percent Pd charcoal / ethanol

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; sodium azide; trimethylamine-N-oxide; hydrogen; sodium carbonate; palladium on activated charcoal; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; benzene; 1: Alkylation / 2: Oxidation / 3: Oxidation / 4: Reduction / 5: Acylation / 6: Substitution / 7: Arylation / 8: Reduction;
DOI:10.3987/COM-99-S78

Reference yield:

: (6-bromo-pyridin-2-yl)-(tert-butyl-dimethyl-silanyloxy)-acetaldehyde

: 263718-69-0
2-(tert-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol; H₂O / 0.17 h / 25 °C

2: 99 percent / DMAP / CH₂Cl₂ / 0.67 h / 0 - 25 °C

3: NaN₃ / dimethylsulfoxide / 25 °C

4: 77 percent / 2M aq. Na₂CO₃ / Pd(Ph₃P)4 / benzene; ethanol / 36 h / reflux

5: 100 percent / H₂ / 5 percent Pd charcoal / ethanol

With dmap; sodium tetrahydroborate; sodium azide; hydrogen; sodium carbonate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; benzene; 1: Reduction / 2: Acylation / 3: Substitution / 4: Arylation / 5: Reduction;
DOI:10.3987/COM-99-S78