[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Base Information

• Chemical Name: [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester
• CAS No.: 177784-11-1
• Molecular Formula: C₂₇H₂₆N₄O₄
• Molecular Weight: 470.528

Synonyms:[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Chemical Property of [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

There total 3 articles about [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3) → [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester (177784-11-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2 h, 2.) DMF, from 0 deg C to RT, 1 h

2: 100 percent / 10percent Pd/C / methanol / 1.5 h

3: tetrahydrofuran / 12 h / 23 °C

With sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00078a018

Reference yield:

ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (119487-58-0) → [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester (177784-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 10percent Pd/C / methanol / 1.5 h

2: tetrahydrofuran / 12 h / 23 °C

palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00078a018

Reference yield:

3-tolyl isocyanate (621-29-4) + ethyl 3(R,S)-amino-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate formate salt → [2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester (177784-11-1)

Guidance literature:

In tetrahydrofuran; at 23 ℃; for 12h; Yield given;

DOI:10.1021/jm00078a018

upstream raw materials:

3-tolyl isocyanate

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Downstream raw materials:

[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid

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