bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine

Base Information

• Chemical Name: bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine
• CAS No.: 851182-97-3
• Molecular Formula: C₂₉H₂₉N₅
• Molecular Weight: 447.583
• Mol file: 851182-97-3.mol

Synonyms:bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine

Chemical Property of bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine

There total 2 articles about bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-methyl-2-phenyl-1H-imidazole-4-carboxaldehyde (94938-02-0) + benzylamine (100-46-9) → bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine (851182-97-3)

Guidance literature:

With 4 A molecular sieve; acetic acid; In methanol; at 70 ℃; for 4h;

DOI:10.1021/jo0481607

Reference yield:

2-phenyl-1H-imidazole-4-carbaldehyde (68282-47-3) → bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine (851182-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0 °C

1.2: 44 percent / dimethylformamide / 3 h / 0 °C

2.1: 75 percent / NaBH(OAc)3; AcOH / tetrahydrofuran

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja047437h

Reference yield: 96.0%

bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]benzylamine (851182-97-3) → bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]amine (851182-98-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 40 ℃; for 7h;

DOI:10.1021/ja047437h

upstream raw materials:

1-methyl-2-phenyl-1H-imidazole-4-carboxaldehyde

benzylamine

2-phenyl-1H-imidazole-4-carbaldehyde

Downstream raw materials:

bis[(1-methyl-2-phenyl-4-imidazolyl)methyl]amine