1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one
CAS No.:857506-69-5
Molecular Formula:C₃₅H₃₀F₂N₂O₆
Molecular Weight:612.63
Hs Code.:

Synonyms:1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

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Chemical Property of 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

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Technology Process of 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

There total 1 articles about 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 857506-80-0
C₃₉H₃₈F₂N₂O₆

: 857506-69-5
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: With formic acid; at 20 - 50 ℃;

Reference yield: 50.0%

: 857506-69-5
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

: 1-(4-fluorophenyl)-3-(R)-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one; With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

With ammonium acetate; In methanol;

Reference yield:

: 857506-69-5
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-(1-(R)-carboxy-2-phenylethyl)carbamoylmethoxy]phenyl}azetidin-2-one

: 48067-24-9
O-tert-butyl L-serine tert-butyl ester

: 857506-58-2
C₄₆H₅₁F₂N₃O₈

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 6h;