48067-24-9

Basic information

• Product Name: H-SER(TBU)-OTBU
• Synonyms: SERINE(TBU)-OTBU;O-T-BUTYL-L-SERINE T-BUTYL ESTER;H-SER(TBU)-OTBU;(S)-tert-Butyl 2-amino-3-tert-butoxypropanoate;L-Serine, O-(1,1-diMethylethyl)-, 1,1-diMethylethyl ester;tert-butyl 2-aMino-3-[(2-Methylpropan-2-yl)oxy]propanoate;L-Ser(tBu)-OtBu;-tert-Butyl 2-amino-3-(tert-butoxy)
• CAS NO: 48067-24-9
• Molecular Formula: C₁₁H₂₃NO₃
• Molecular Weight: 217.31
• Mol File: 48067-24-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 283.8°C at 760 mmHg
• Flash Point: 81.3°C
• Appearance: /
• Density: 0.969g/cm³
• Vapor Pressure: 0.0031mmHg at 25°C
• Refractive Index: 1.447
• Storage Temp.: -15°C
• PKA: 6.11±0.33(Predicted)
• CAS DataBase Reference: H-SER(TBU)-OTBU(CAS DataBase Reference)
• NIST Chemistry Reference: H-SER(TBU)-OTBU(48067-24-9)
• EPA Substance Registry System: H-SER(TBU)-OTBU(48067-24-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 48067-24-9(Hazardous Substances Data)

Usage

General Description

H-SER(TBU)-OTBU, also known as N-tert-butoxycarbonyl-O-tert-butyl-L-serine, is a chemical compound often used in peptide chemistry. It is a derivative of L-serine, an amino acid crucial for protein synthesis and neurotransmitter function in the human body. H-SER(TBU)-OTBU is commonly used as a building block in the synthesis of peptides and other biomolecules due to its ability to protect the hydroxyl group of the serine residue, allowing for selective manipulation of the amino acid sequence. H-SER(TBU)-OTBU is a versatile tool in the field of organic and bioorganic chemistry, enabling the creation of diverse peptide structures with specific functional groups for a wide range of applications in drug discovery, biotechnology, and materials science.

InChI:InChI=1/C11H23NO3/c1-10(2,3)14-7-8(12)9(13)15-11(4,5)6/h8H,7,12H2,1-6H3/t8-/m0/s1

Upstream product

• 51537-21-4 O-tert-butyl-L-serine tert-butyl ester hydrochloride 
• 540-88-5 acetic acid tert-butyl ester 
• 56-45-1 L-serin 
• 1634-04-4 tert-butyl methyl ether 
• 104669-71-8 N^α-carboallyloxy-O-tert-butylserine tert-butyl ester 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 115-11-7 isobutene 
• 58455-98-4 O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester 

Downstream Products

• 134982-11-9 Z-Gly-Ser(Bu^t)-OBu^t 
• 876291-40-6 3-tert-butoxy-2-{2-[4,5-dichloro-2-(4-fluoro-phenyl)-6-methoxy-1,3-dioxo-indan-2-yl]-ethylamino}-propionic acid tert-butyl ester 
• 1011478-89-9 (S)-2-(4-bromo-2-hydroxy-benzoylamino)-3-tert-butoxy-propionic acid tert-butyl ester 
• 1011479-42-7 (S)-3-tert-butoxy-2-{[3'-(9H-fluoren-9-ylmethoxycarbonylamino)biphenyl-4-carbonyl]amino}propionic acid tert-butyl ester 
• 161878-82-6 (S)-4-((S)-2-tert-Butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester 
• 90551-71-6 Aloc-Met-Phe-Ala-Ser(tBu)-OtBu 
• 86050-06-8 N-<2-(Triphenylphosphonio)ethoxycarbonyl>-O-tert-butylserin-tert-butylester-chlorid 
• 1093799-21-3 C₁₉H₃₀N₂O₆ 
• 1416579-64-0 C₃₇H₅₅N₃O₉ 
• 1416579-65-1 C₂₉H₄₉N₃O₇ 
• 1416579-66-2 C₃₁H₅₀ClN₃O₈ 
• 1416579-67-3 C₄₇H₆₇FN₆O₁₁ 
• 1026986-63-9 C₂₈H₄₈N₂O₆S 

Relevant articles and documents

Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N-And C-Termini of Dipeptide

A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-Terminal unprotected am

Heterocyclic derivatives with immunomodulatory effects

The invention relates to novel heterocyclic derivatives with immunomodulatory effects capable of inhibiting therapeutic agents in a programmed cell death (PD1) signal path. The compounds disclosed bythe invention are capable of enhancing antitumor activit

Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy

As a further extension of our research work focusing on the development of gold(III)-dithiocarbamato dtc derivatives of oligopeptides as potential anticancer agents, complexes [AuIIIX2(dtc-Sar-l-Ser(t-Bu)- O(t-Bu))] (X = Br (1a)/Cl (