2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

Base Information

Chemical Name:2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile
CAS No.:280120-51-6
Molecular Formula:C₂₇H₁₅F₅N₄O₂
Molecular Weight:522.434
Hs Code.:

2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-<i>c</i>]pyridin-1-yl]-benzonitrile

Synonyms:2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

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Chemical Property of 2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

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Technology Process of 2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

There total 10 articles about 2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 905931-55-7
2-fluoro-5-[6-(2-fluoro-4-iodo-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

: 40138-16-7
2-formylbenzene boronic acid

: 280120-51-6
2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2006.02.069

Reference yield:

: 916590-30-2
1-(2-fluoro-4-iodophenyl)piperidin-2-one

: 280120-51-6
2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / CHCl₃ / Heating

2.1: 140 °C

3.1: DMAP / CH₂Cl₂

3.2: aq. HCl / diethyl ether

4.1: methanol

5.1: 85 percent / (Ph₃P)4Pd; K₃PO₄ / dioxane

With dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; In 1,4-dioxane; methanol; dichloromethane; chloroform; 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069

Reference yield:

: 916591-48-5
3,3-dichloro-1-(2-fluoro-4-iodo-phenyl)-piperidin-2-one

: 280120-51-6
2-fluoro-5-[6-(3-fluoro-2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 140 °C

2.1: DMAP / CH₂Cl₂

2.2: aq. HCl / diethyl ether

3.1: methanol

4.1: 85 percent / (Ph₃P)4Pd; K₃PO₄ / dioxane

With dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; 4.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069