(-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

Base Information

Chemical Name:(-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol
CAS No.:1072145-61-9
Molecular Formula:C₂₁H₂₈O₆Si
Molecular Weight:404.535
Hs Code.:

Synonyms:(-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

Chemical Property:

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Technology Process of (-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

There total 9 articles about (-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1072145-55-1
(+)-4'-tert-butyldimethylsilyloxy-2',7-(dibenzyloxy)isoflavan-3,4-diol

: 1072145-61-9
(-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In acetone;
DOI:10.1021/jm101619e

Reference yield:

: 1186507-06-1
2-benzyloxy-4-methoxymethyloxy-4'-benzyloxy-2'-acetoxychalcone

: 1072145-61-9
(-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

Guidance literature:: Multi-step reaction with 6 steps

1.1: thallium(III) nitrate trihydrate / methanol; dichloromethane / 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / Reflux; Inert atmosphere

3.1: triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.2: 2 h / 0 - 60 °C / Inert atmosphere

5.1: osmium(VIII) oxide; AD-mix-β / dichloromethane / -78 °C

6.1: palladium 10% on activated carbon; hydrogen / acetone

With hydrogenchloride; osmium(VIII) oxide; lithium borohydride; thallium(III) nitrate trihydrate; palladium 10% on activated carbon; AD-mix-β; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/jm101619e

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 1072145-61-9
(-)-4'-t-butyldimethylsilyloxy-2',7-dihydroxyisoflavan-3,4-diol

Guidance literature:: Multi-step reaction with 8 steps

1.1: piperidine / methanol / 60 °C / Inert atmosphere

2.1: triethylamine / Inert atmosphere

3.1: thallium(III) nitrate trihydrate / methanol; dichloromethane / 20 °C / Inert atmosphere

4.1: hydrogenchloride / water / Reflux; Inert atmosphere

5.1: triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

6.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6.2: 2 h / 0 - 60 °C / Inert atmosphere

7.1: osmium(VIII) oxide; AD-mix-β / dichloromethane / -78 °C

8.1: palladium 10% on activated carbon; hydrogen / acetone

With piperidine; hydrogenchloride; osmium(VIII) oxide; lithium borohydride; thallium(III) nitrate trihydrate; palladium 10% on activated carbon; AD-mix-β; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; 1.1: Claisen Schmidt condensation;
DOI:10.1021/jm101619e