Technology Process of (+)-4'-tert-butyldimethylsilyloxy-2',7-(dibenzyloxy)isoflavan-3,4-diol
There total 18 articles about (+)-4'-tert-butyldimethylsilyloxy-2',7-(dibenzyloxy)isoflavan-3,4-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; hydroquinidine 1 4-phthalazinediyl diether;
In
dichloromethane;
at -20 ℃;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/op200112g
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate / acetone / Reflux; Inert atmosphere
3.1: acetonitrile / Inert atmosphere
4.1: potassium tert-butylate / methanol / Inert atmosphere; Reflux
5.1: triphenylphosphine hydrobromide / dichloromethane / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: osmium(VIII) oxide; hydroquinidine 1 4-phthalazinediyl diether / dichloromethane / -20 °C
With
sodium tetrahydroborate; osmium(VIII) oxide; hydroquinidine 1 4-phthalazinediyl diether; potassium tert-butylate; triphenylphosphine hydrobromide; potassium carbonate;
In
methanol; dichloromethane; acetone; acetonitrile;
4.1: Wittig reaction / 6.1: Sharpless dihydroxylation;
DOI:10.1021/op200112g
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere
1.2: 10 h / Reflux; Inert atmosphere
2.1: piperidine / methanol / 60 °C / Inert atmosphere
3.1: triethylamine / Inert atmosphere
4.1: thallium(III) nitrate trihydrate / methanol; dichloromethane / 20 °C / Inert atmosphere
5.1: hydrogenchloride / water / Reflux; Inert atmosphere
6.1: triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere
7.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
7.2: 2 h / 0 - 60 °C / Inert atmosphere
8.1: osmium(VIII) oxide; AD-mix-β / dichloromethane / -78 °C
With
piperidine; hydrogenchloride; osmium(VIII) oxide; lithium borohydride; thallium(III) nitrate trihydrate; AD-mix-β; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
2.1: Claisen Schmidt condensation;
DOI:10.1021/jm101619e
