5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

Base Information

Chemical Name:5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole
CAS No.:1270931-12-8
Molecular Formula:C₁₇H₁₆F₃N₃O₂S₂
Molecular Weight:415.46
Hs Code.:

Synonyms:5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

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Technology Process of 5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

There total 5 articles about 5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1270931-20-8
4-iodo-5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

: 1270931-12-8
5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

Guidance literature:: With platinum on carbon; hydrogen; In ethanol; at 20 ℃; for 18h;
DOI:10.1002/jlcr.1804

Reference yield: 29.0%

: 1179925-22-4
C₉H₁₃NO₂S₂

: 210107-38-3
3-(4-iodophenyl)-3-(trifluoromethyl)-3H-diazirine

: 1270931-12-8
5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(diphenylphosphino)ferrocene; triethylamine; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 5h; Inert atmosphere; Darkness;
DOI:10.1002/jlcr.1804

Reference yield:

: C₉H₁₂INO₂S₂

: 1270931-12-8
5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: methanol

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(diphenylphosphino)ferrocene; triethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 60 °C / Inert atmosphere; Darkness

3: platinum on carbon; hydrogen / ethanol / 18 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(diphenylphosphino)ferrocene; platinum on carbon; hydrogen; triethylamine; In 1-methyl-pyrrolidin-2-one; methanol; ethanol;
DOI:10.1002/jlcr.1804