(Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Base Information

Chemical Name:(Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole
CAS No.:1388841-38-0
Molecular Formula:C₁₂H₈ClN₅O
Molecular Weight:273.681
Hs Code.:

Synonyms:(Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

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Chemical Property of (Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

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Technology Process of (Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

There total 4 articles about (Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.2%

: 1388841-96-0
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

: 122-51-0
orthoformic acid triethyl ester

: 1388841-38-0
(Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Guidance literature:: methanesulfonic acid; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1333151-42-0
(Z)-3-[3-(3-chlorophenyl)-[1,2,4]-triazol-1-yl]acrylic acid isopropyl ester

: 1388841-38-0
(Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

1.2: pH 4

2.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: hydrazine hydrate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: methanesulfonic acid / 1 h / 80 °C / Inert atmosphere

With 4-methyl-morpholine; water; hydrazine hydrate; lithium hydroxide; methanesulfonic acid; In tetrahydrofuran;

Reference yield:

: 1333152-88-7
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 1388841-38-0
(Z)-2-(2-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: hydrazine hydrate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: methanesulfonic acid / 1 h / 80 °C / Inert atmosphere

With 4-methyl-morpholine; hydrazine hydrate; methanesulfonic acid; In tetrahydrofuran;