(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

Base Information

Chemical Name:(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride
CAS No.:1333153-17-5
Molecular Formula:C₁₆H₁₆ClN₃O₄
Molecular Weight:349.774
Hs Code.:

Synonyms:(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

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Chemical Property of (Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

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Technology Process of (Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

There total 6 articles about (Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333152-88-7
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 543-27-1
isobutyl chloroformate

: 1333153-17-5
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

Reference yield:

: 766-84-7
3-chloro-benzonitrile

: 1333153-17-5
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

Guidance literature:: Multi-step reaction with 6 steps

1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 2 h / 20 °C

2: diethyl ether / 24 h

3: N,N-dimethyl-formamide / 90 °C / Inert atmosphere

4: triethylamine / acetonitrile / 90 °C / Inert atmosphere; Cooling

5: water; lithium hydroxide / tetrahydrofuran / 20 °C

6: 4-methyl-morpholine / tetrahydrofuran / 0 °C / Inert atmosphere

With 4-methyl-morpholine; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; triethylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1333151-42-0
(Z)-3-[3-(3-chlorophenyl)-[1,2,4]-triazol-1-yl]acrylic acid isopropyl ester

: 1333153-17-5
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutylcarbonic) anhydride

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: 4-methyl-morpholine / tetrahydrofuran / 0 °C / Inert atmosphere

With 4-methyl-morpholine; water; lithium hydroxide; In tetrahydrofuran;