2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

Base Information

Chemical Name:2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite
CAS No.:1313022-61-5
Molecular Formula:C₅₁H₆₂N₁₁O₁₁P
Molecular Weight:1036.09
Hs Code.:

2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

Synonyms:2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

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Chemical Property of 2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

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Technology Process of 2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

There total 7 articles about 2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1313022-60-4
N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)-N-((1-(2-(2-(uracil-1-yl)-N-(2-hydroxyethyl)acetamido)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1313022-61-5
2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/jhet.532

Reference yield:

: 924906-60-5
N-(prop-2-ynyl)-N-[2-(tert-butyldimethylsilanyloxy)ethyl]amine

: 1313022-61-5
2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

1.2: 24 h / 20 °C

2.1: copper(II) sulfate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 24 h / 20 °C

3.1: lithium borohydride / tetrahydrofuran; methanol / 1.5 h / Reflux

4.1: pyridine / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

6.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

With dmap; lithium borohydride; tetrabutyl ammonium fluoride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/jhet.532

Reference yield:

: 1313022-54-6
N-(2-(tert-butyldimethylsilyloxy)ethyl)-uracil-1-yl-N-(prop-2-yn-1-yl)acetamide

: 1313022-61-5
2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: copper(II) sulfate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 24 h / 20 °C

2: lithium borohydride / tetrahydrofuran; methanol / 1.5 h / Reflux

3: pyridine / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

5: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

With dmap; lithium borohydride; tetrabutyl ammonium fluoride; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/jhet.532