methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Base Information

Chemical Name:methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate
CAS No.:1416961-14-2
Molecular Formula:C₂₀H₃₅NO₈S
Molecular Weight:449.566
Hs Code.:

Synonyms:methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Suppliers and Price of methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

There total 4 articles about methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 877664-10-3
methyl trans-4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 124-63-0
methanesulfonyl chloride

: 1416961-14-2
methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 877664-08-9
methyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

: 1416961-14-2
methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Rh/Al₂O₃; hydrogen / acetic acid; ethanol / 2.5 h / 20 °C / 8?atm

2: sodium methylate / methanol / Reflux

3: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

With Rh/Al₂O₃; hydrogen; sodium methylate; triethylamine; diazomethyl-trimethyl-silane; In methanol; ethanol; hexane; dichloromethane; acetic acid; benzene;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: C₁₈H₃₁NO₆

: 1416961-14-2
methyl trans-4-[1-tert-butoxycarbonyl-(5S)-methanesulfonyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 °C

With triethylamine; diazomethyl-trimethyl-silane; In hexane; dichloromethane; benzene;
DOI:10.1016/j.bmc.2012.11.003