5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid
CAS No.:1394019-63-6
Molecular Formula:C₂₄H₂₃N₃O₅
Molecular Weight:433.464
Hs Code.:

Synonyms:5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

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Chemical Property of 5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

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Technology Process of 5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

There total 5 articles about 5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3112-31-0
3,5-pyrazoledicarboxylic acid

: 1394019-96-5
1-((R)-2-amino-3-biphenyl-4-yl-propyl)cyclopropanecarboxylic acid

: ammonium chloride

: 1394019-63-6
5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

Guidance literature:: With DIPEA; acetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: 1394019-93-2
C₂₇H₃₅NO₄

: 1394019-63-6
5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C

3.2: 1 h

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1394019-95-4
1-((R)-3-biphenyl-4-yl-2-t-butoxycarbonylaminopropyl)cyclopropanecarboxylic acid t-butyl ester

: 1394019-63-6
5-[(R)-2-biphenyl-4-yl-1-(1-carboxycyclopropylmethyl)ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C

2.2: 1 h

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;