N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine

Base Information

• Chemical Name: N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine
• CAS No.: 865536-37-4
• Molecular Formula: C₁₄H₁₈N₄O₂
• Molecular Weight: 274.323
• Mol file: 865536-37-4.mol

Synonyms:N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine

Chemical Property of N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine

There total 1 articles about N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methyl-6-nitroquinoline (54965-59-2) + N,N-dimethylethylenediamine (108-00-9) → N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine (865536-37-4)

Guidance literature:

In ethanol; at 55 ℃; for 24h;

DOI:10.1016/j.ejmech.2017.07.080

Reference yield:

N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine (865536-37-4) → tert-butyl (2-dimethylaminoethyl)-{4-methyl-6-[(E)-3-(4-trifluoromethoxyphenyl)acryloylamino]quinolin-2-yl}carbamate (865536-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 76 percent / H₂ / Pd/C / tetrahydrofuran / 12 h / 760 Torr

3: 98 percent / CH₂Cl₂ / 3 h

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm050103y

Reference yield:

N,N-dimethyl-N'-(4-methyl-6-nitroquinolin-2-yl)ethane-1,2-diamine (865536-37-4) → N-[2-(2-dimethylamino-ethylamino)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 76 percent / H₂ / Pd/C / tetrahydrofuran / 12 h / 760 Torr

3: 98 percent / CH₂Cl₂ / 3 h

4: 70 percent / TFA / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm050103y

upstream raw materials:

2-chloro-4-methyl-6-nitroquinoline

N,N-dimethylethylenediamine

Downstream raw materials:

tert-butyl (2-dimethylaminoethyl)-{4-methyl-6-[(E)-3-(4-trifluoromethoxyphenyl)acryloylamino]quinolin-2-yl}carbamate