(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester
CAS No.:177567-44-1
Molecular Formula:C₂₆H₃₂ClNO₆
Molecular Weight:489.996
Hs Code.:

Synonyms:(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

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Chemical Property of (E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

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Technology Process of (E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

There total 7 articles about (E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 26367-48-6
fumaric acid ethyl ester mono chloride

: 177410-77-4
(S)-[5-Chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2,3-dimethoxy-phenyl)-methanol

: 177567-44-1
(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 0.666667h;
DOI:10.1248/cpb.50.59

Reference yield:

: 152911-54-1
(+/-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol

: 177567-44-1
(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / NaHCO₃; DMAP / ethyl acetate / 1 h / 20 °C

2: 86 percent / pyridine; DMAP / 1 h / 20 °C

3: 25 percent / Pseudomonas sp. S-13; H₂O / methanol; various solvent(s) / 24 h / 28 °C

4: 86 percent / NaOH / ethanol / 3 h / Heating

5: 73 percent / NaBH₄; AcOH / 0.33 h / 20 °C

6: 99 percent / NaHCO₃ / ethyl acetate / 0.67 h / 20 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; Pseudomonas sp. S-13; water; sodium hydrogencarbonate; acetic acid; In methanol; ethanol; ethyl acetate;
DOI:10.1248/cpb.50.59

Reference yield:

: 177410-73-0
(+/-)-5-chloro-α-(2,3-dimethoxyphenyl)-2-pivaloylaminobenzyl alcohol

: 177567-44-1
(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / pyridine; DMAP / 1 h / 20 °C

2: 25 percent / Pseudomonas sp. S-13; H₂O / methanol; various solvent(s) / 24 h / 28 °C

3: 86 percent / NaOH / ethanol / 3 h / Heating

4: 73 percent / NaBH₄; AcOH / 0.33 h / 20 °C

5: 99 percent / NaHCO₃ / ethyl acetate / 0.67 h / 20 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; Pseudomonas sp. S-13; water; sodium hydrogencarbonate; acetic acid; In methanol; ethanol; ethyl acetate;
DOI:10.1248/cpb.50.59